Symbol: Name: ID: |
HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 GFS:5969 |
Gene name: | HCN4 |
Chromosome: | 15q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1298209 | Rat Genome Database ID: | RGD:71065 |
HGNC ID: | HGNC:16882 | RefSeq IDs: | NM_005477 |
Entrez Gene ID: | 10021 | Ensembl Gene ID: | ENSG00000138622 |
VEGA IDs: | OTTHUMG00000137563 | UniProt ID: | Q9Y3Q4 |
UCSC ID: | uc002avp.2 | OMIM ID: | 605206 |
Pubmed: | PMID10228147 PMID 10430953 PMID 16382102 | ||
CCDS IDs: | CCDSCCDS10248.1 |
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.
Products for HCN4 gene
Catalog | Product Name | Application | Company |
GFS:E05969 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4; ELISA kit | ELISA | n/a |
GFS:A05969 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4; Anti | ANTIBODIES | n/a |
GFS:P05969 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4; Protien | Protien | n/a |