Symbol: Name: ID: |
HIPK2 homeodomain interacting protein kinase 2 GFS:3745 |
Gene name: | HIPK2 |
Chromosome: | 7q32-q34 |
Previous Symbols: | |
Previous Names: | homeodomain-interacting protein kinase 2 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1314872 | Rat Genome Database ID: | RGD:1309349 |
HGNC ID: | HGNC:14402 | RefSeq IDs: | NM_001113239 |
Entrez Gene ID: | 28996 | Ensembl Gene ID: | ENSG00000064393 |
VEGA IDs: | OTTHUMG00000157704 | UniProt ID: | Q9H2X6 |
UCSC ID: | uc003vvf.3 | OMIM ID: | 606868 |
Pubmed: | PMID11120354 | ||
CCDS IDs: |
Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.
HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.[supplied by OMIM, Jul 2002].
Function: Protein kinase acting as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. Phosphorylation of TP53 may be mediated by a TP53-HIPK2-AXIN1 complex. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB (By similarity). Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Products for HIPK2 gene
Catalog | Product Name | Application | Company |
GFS:E03745 | homeodomain interacting protein kinase 2; ELISA kit | ELISA | n/a |
GFS:A03745 | homeodomain interacting protein kinase 2; Anti | ANTIBODIES | n/a |
GFS:P03745 | homeodomain interacting protein kinase 2; Protien | Protien | n/a |