Symbol: Name: ID: |
HMHA1 histocompatibility (minor) HA-1 GFS:6196 |
Gene name: | HMHA1 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0223, HA-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917969 | Rat Genome Database ID: | RGD:1308662 |
HGNC ID: | HGNC:17102 | RefSeq IDs: | NM_012292 |
Entrez Gene ID: | 23526 | Ensembl Gene ID: | ENSG00000180448 |
VEGA IDs: | UniProt ID: | Q92619 | |
UCSC ID: | uc002lqz.1 | OMIM ID: | 601155 |
Pubmed: | PMID9820596 PMID 9039502 | ||
CCDS IDs: | CCDSCCDS32863.1 |
Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.
Function: GTPase activator for the Rho-type GTPases (Potential)
Function: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
Products for HMHA1 gene
Catalog | Product Name | Application | Company |
GFS:E06196 | histocompatibility (minor) HA-1; ELISA kit | ELISA | n/a |
GFS:A06196 | histocompatibility (minor) HA-1; Anti | ANTIBODIES | n/a |
GFS:P06196 | histocompatibility (minor) HA-1; Protien | Protien | n/a |