Symbol: Name: ID: |
HAVCR2 hepatitis A virus cellular receptor 2 GFS:7288 |
Gene name: | HAVCR2 |
Chromosome: | 5q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Tim-3, TIM3, FLJ14428, TIMD3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2159682 | Rat Genome Database ID: | RGD:1305233 |
HGNC ID: | HGNC:18437 | RefSeq IDs: | NM_032782 |
Entrez Gene ID: | 84868 | Ensembl Gene ID: | ENSG00000135077 |
VEGA IDs: | OTTHUMG00000130249 | UniProt ID: | Q8TDQ0 |
UCSC ID: | uc003lwk.1 | OMIM ID: | 606652 |
Pubmed: | PMID11823861 | ||
CCDS IDs: | CCDSCCDS4333.1 |
Hepatitis A virus cellular receptor 2 is a protein that in humans is encoded by the HAVCR2 gene.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011].
Function: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
Products for HAVCR2 gene
Catalog | Product Name | Application | Company |
GFS:E07288 | hepatitis A virus cellular receptor 2; ELISA kit | ELISA | n/a |
GFS:A07288 | hepatitis A virus cellular receptor 2; Anti | ANTIBODIES | n/a |
GFS:P07288 | hepatitis A virus cellular receptor 2; Protien | Protien | n/a |