Symbol: Name: ID: |
HPGDS hematopoietic prostaglandin D synthase GFS:6792 |
Gene name: | HPGDS |
Chromosome: | 4q22.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GSTS, PGDS, H-PGDS |
Name Aliases: | glutathione S-transferase sigma |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1859384 | Rat Genome Database ID: | RGD:69251 |
HGNC ID: | HGNC:17890 | RefSeq IDs: | NM_014485 |
Entrez Gene ID: | 27306 | Ensembl Gene ID: | ENSG00000163106 |
VEGA IDs: | OTTHUMG00000130974 | UniProt ID: | O60760 |
UCSC ID: | uc003hte.1 | OMIM ID: | 602598 |
Pubmed: | PMID9323136 PMID 9353279 PMID 11672424 | ||
CCDS IDs: | CCDSCCDS3640.1 |
PGDS protein is a protein that in humans is encoded by the HPGDS gene.
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Products for HPGDS gene
Catalog | Product Name | Application | Company |
GFS:E06792 | hematopoietic prostaglandin D synthase; ELISA kit | ELISA | n/a |
GFS:A06792 | hematopoietic prostaglandin D synthase; Anti | ANTIBODIES | n/a |
GFS:P06792 | hematopoietic prostaglandin D synthase; Protien | Protien | n/a |