Symbol: Name: ID: |
HHIP hedgehog interacting protein GFS:4153 |
Gene name: | HHIP |
Chromosome: | 4q31.21-q31.3 |
Previous Symbols: | |
Previous Names: | hedgehog-interacting protein |
Aliases: | HIP, FLJ20992 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1341847 | Rat Genome Database ID: | RGD:1564108 |
HGNC ID: | HGNC:14866 | RefSeq IDs: | NM_022475 |
Entrez Gene ID: | 64399 | Ensembl Gene ID: | ENSG00000164161 |
VEGA IDs: | UniProt ID: | Q96QV1 | |
UCSC ID: | uc003ijs.1 | OMIM ID: | 606178 |
Pubmed: | PMID11435703 PMID 11731473 | ||
CCDS IDs: | CCDSCCDS3762.1 |
Hedgehog-interacting protein is a protein that in humans is encoded by the HHIP gene.
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Products for HHIP gene
Catalog | Product Name | Application | Company |
GFS:E04153 | hedgehog interacting protein; ELISA kit | ELISA | n/a |
GFS:A04153 | hedgehog interacting protein; Anti | ANTIBODIES | n/a |
GFS:P04153 | hedgehog interacting protein; Protien | Protien | n/a |