Symbol: Name: ID: |
GREM2 gremlin 2 GFS:6607 |
Gene name: | GREM2 |
Chromosome: | 1q43 |
Previous Symbols: | |
Previous Names: | gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) |
Aliases: | Prdc, FLJ21195, CKTSF1B2, DAND3 |
Name Aliases: | protein related to DAN and cerberus |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344367 | Rat Genome Database ID: | RGD:1560008 |
HGNC ID: | HGNC:17655 | RefSeq IDs: | NM_022469 |
Entrez Gene ID: | 64388 | Ensembl Gene ID: | ENSG00000180875 |
VEGA IDs: | OTTHUMG00000039909 | UniProt ID: | Q9H772 |
UCSC ID: | uc001hys.2 | OMIM ID: | 608832 |
Pubmed: | PMID15039429 | ||
CCDS IDs: | CCDSCCDS31070.1 |
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008].
Function: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity).
Products for GREM2 gene
Catalog | Product Name | Application | Company |
GFS:E06607 | gremlin 2; ELISA kit | ELISA | n/a |
GFS:A06607 | gremlin 2; Anti | ANTIBODIES | n/a |
GFS:P06607 | gremlin 2; Protien | Protien | n/a |