Symbol: Name: ID: |
GLRX3 glutaredoxin 3 GFS:5117 |
Gene name: | GLRX3 |
Chromosome: | 10q26 |
Previous Symbols: | TXNL2 |
Previous Names: | thioredoxin-like 2 |
Aliases: | PICOT, bA500G10.4, GRX3, GLRX4, GRX4 |
Name Aliases: | glutaredoxin 4 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353653 | Rat Genome Database ID: | RGD:69414 |
HGNC ID: | HGNC:15987 | RefSeq IDs: | NM_001199868 |
Entrez Gene ID: | 10539 | Ensembl Gene ID: | ENSG00000108010 |
VEGA IDs: | OTTHUMG00000019267 | UniProt ID: | O76003 |
UCSC ID: | uc001lkm.1 | OMIM ID: | 612754 |
Pubmed: | PMID10636891 PMID 11124703 | ||
CCDS IDs: | CCDSCCDS7661.1 |
Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene.
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
Function: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Products for GLRX3 gene
Catalog | Product Name | Application | Company |
GFS:E05117 | glutaredoxin 3; ELISA kit | ELISA | n/a |
GFS:A05117 | glutaredoxin 3; Anti | ANTIBODIES | n/a |
GFS:P05117 | glutaredoxin 3; Protien | Protien | n/a |