Symbol: Name: ID: |
GMNN geminin, DNA replication inhibitor GFS:6519 |
Gene name: | GMNN |
Chromosome: | 6p21.32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Gem |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927344 | Rat Genome Database ID: | RGD:1308137 |
HGNC ID: | HGNC:17493 | RefSeq IDs: | NM_015895 |
Entrez Gene ID: | 51053 | Ensembl Gene ID: | ENSG00000112312 |
VEGA IDs: | OTTHUMG00000014363 | UniProt ID: | O75496 |
UCSC ID: | uc003nen.2 | OMIM ID: | 602842 |
Pubmed: | PMID9635433 | ||
CCDS IDs: | CCDSCCDS4560.1 |
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene.
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
Function: Inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Products for GMNN gene
Catalog | Product Name | Application | Company |
GFS:E06519 | geminin, DNA replication inhibitor; ELISA kit | ELISA | n/a |
GFS:A06519 | geminin, DNA replication inhibitor; Anti | ANTIBODIES | n/a |
GFS:P06519 | geminin, DNA replication inhibitor; Protien | Protien | n/a |