Symbol: Name: ID: |
FNBP1 formin binding protein 1 GFS:6162 |
Gene name: | FNBP1 |
Chromosome: | 9q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FBP17, KIAA0554 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109606 | Rat Genome Database ID: | RGD:621350 |
HGNC ID: | HGNC:17069 | RefSeq IDs: | NM_015033 |
Entrez Gene ID: | 23048 | Ensembl Gene ID: | ENSG00000187239 |
VEGA IDs: | OTTHUMG00000020800 | UniProt ID: | Q96RU3 |
UCSC ID: | uc004byw.1 | OMIM ID: | 606191 |
Pubmed: | PMID9628581 PMID 11438682 | ||
CCDS IDs: | CCDSCCDS48040.1 |
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Products for FNBP1 gene
Catalog | Product Name | Application | Company |
GFS:E06162 | formin binding protein 1; ELISA kit | ELISA | n/a |
GFS:A06162 | formin binding protein 1; Anti | ANTIBODIES | n/a |
GFS:P06162 | formin binding protein 1; Protien | Protien | n/a |