Symbol: Name: ID: |
FOXP2 forkhead box P2 GFS:3336 |
Gene name: | FOXP2 |
Chromosome: | 7q31 |
Previous Symbols: | TNRC10, SPCH1 |
Previous Names: | |
Aliases: | CAGH44 |
Name Aliases: | trinucleotide repeat containing 10, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2148705 | Rat Genome Database ID: | RGD:1559697 |
HGNC ID: | HGNC:13875 | RefSeq IDs: | NM_001172766 |
Entrez Gene ID: | 93986 | Ensembl Gene ID: | ENSG00000128573 |
VEGA IDs: | OTTHUMG00000023131 | UniProt ID: | O15409 |
UCSC ID: | uc003vgz.2 | OMIM ID: | 605317 |
Pubmed: | PMID11586359 PMID 9225980 | ||
CCDS IDs: | CCDSCCDS5760.1 CCDS CCDS5761.1 CCDS CCDS43635.1 |
Forkhead box protein P2 also known as FOXP2 is a protein that in humans is encoded by the FOXP2 gene.
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
Function: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.
Products for FOXP2 gene
Catalog | Product Name | Application | Company |
GFS:E03336 | forkhead box P2; ELISA kit | ELISA | n/a |
GFS:A03336 | forkhead box P2; Anti | ANTIBODIES | n/a |
GFS:P03336 | forkhead box P2; Protien | Protien | n/a |