Symbol: Name: ID: |
FOXL2 forkhead box L2 GFS:829 |
Gene name: | FOXL2 |
Chromosome: | 3q23 |
Previous Symbols: | BPES |
Previous Names: | |
Aliases: | BPES1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349428 | Rat Genome Database ID: | RGD:1310041 |
HGNC ID: | HGNC:1092 | RefSeq IDs: | NM_023067 |
Entrez Gene ID: | 668 | Ensembl Gene ID: | ENSG00000183770 |
VEGA IDs: | OTTHUMG00000159889 | UniProt ID: | P58012 |
UCSC ID: | uc003esw.2 | OMIM ID: | 605597 |
Pubmed: | PMID1941972 | ||
CCDS IDs: | CCDSCCDS3105.1 |
Forkhead box protein L2 is a protein that in humans is encoded by the FOXL2 gene. This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Products for FOXL2 gene
Catalog | Product Name | Application | Company |
GFS:E00829 | forkhead box L2; ELISA kit | ELISA | n/a |
GFS:A00829 | forkhead box L2; Anti | ANTIBODIES | n/a |
GFS:P00829 | forkhead box L2; Protien | Protien | n/a |