Symbol: Name: ID: |
EZR ezrin GFS:2466 |
Gene name: | EZR |
Chromosome: | 6q25.3 |
Previous Symbols: | VIL2 |
Previous Names: | villin 2 (ezrin) |
Aliases: | |
Name Aliases: | cytovillin 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98931 | Rat Genome Database ID: | RGD:621161 |
HGNC ID: | HGNC:12691 | RefSeq IDs: | NM_001111077 |
Entrez Gene ID: | 7430 | Ensembl Gene ID: | ENSG00000092820 |
VEGA IDs: | OTTHUMG00000015917 | UniProt ID: | P15311 |
UCSC ID: | uc003qrt.3 | OMIM ID: | 123900 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS5258.1 |
Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq].
Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Products for EZR gene
Catalog | Product Name | Application | Company |
GFS:E02466 | ezrin; ELISA kit | ELISA | n/a |
GFS:A02466 | ezrin; Anti | ANTIBODIES | n/a |
GFS:P02466 | ezrin; Protien | Protien | n/a |