Symbol: Name: ID: |
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) GFS:5943 |
Gene name: | ESPL1 |
Chromosome: | 12q13.13 |
Previous Symbols: | |
Previous Names: | extra spindle poles like 1 (S. cerevisiae) |
Aliases: | KIAA0165, ESP1 |
Name Aliases: | separin, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146156 | Rat Genome Database ID: | RGD:1306266 |
HGNC ID: | HGNC:16856 | RefSeq IDs: | NM_012291 |
Entrez Gene ID: | 9700 | Ensembl Gene ID: | ENSG00000135476 |
VEGA IDs: | UniProt ID: | Q14674 | |
UCSC ID: | uc001sck.2 | OMIM ID: | 604143 |
Pubmed: | PMID8724849 PMID 16258266 | ||
CCDS IDs: | CCDSCCDS8852.1 |
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Products for ESPL1 gene
Catalog | Product Name | Application | Company |
GFS:E05943 | extra spindle pole bodies homolog 1 (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A05943 | extra spindle pole bodies homolog 1 (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P05943 | extra spindle pole bodies homolog 1 (S. cerevisiae); Protien | Protien | n/a |