Symbol: Name: ID: |
EXOSC3 exosome component 3 GFS:6843 |
Gene name: | EXOSC3 |
Chromosome: | 9p11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | hRrp40p, Rrp40p, RRP40, CGI-102, p10, hRrp-40 |
Name Aliases: | exosome component Rrp40, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913612 | Rat Genome Database ID: | RGD:1304739 |
HGNC ID: | HGNC:17944 | RefSeq IDs: | NM_001002269 |
Entrez Gene ID: | 51010 | Ensembl Gene ID: | ENSG00000107371 |
VEGA IDs: | OTTHUMG00000019932 | UniProt ID: | Q9NQT5 |
UCSC ID: | uc010mly.1 | OMIM ID: | 606489 |
Pubmed: | PMID10810093 PMID 11110791 | ||
CCDS IDs: | CCDSCCDS35016.1 CCDS CCDS43805.1 |
Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.
Function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.
Products for EXOSC3 gene
Catalog | Product Name | Application | Company |
GFS:E06843 | exosome component 3; ELISA kit | ELISA | n/a |
GFS:A06843 | exosome component 3; Anti | ANTIBODIES | n/a |
GFS:P06843 | exosome component 3; Protien | Protien | n/a |