| Symbol: Name: ID: |
ERBB2IP erbb2 interacting protein GFS:4980 |
| Gene name: | ERBB2IP |
| Chromosome: | 5p14.3-q12.3 |
| Previous Symbols: | |
| Previous Names: | erbb2-interacting protein |
| Aliases: | ERBIN, LAP2 |
| Name Aliases: | densin-180-like protein, |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1890169 | Rat Genome Database ID: | |
| HGNC ID: | HGNC:15842 | RefSeq IDs: | NM_001006600 |
| Entrez Gene ID: | 55914 | Ensembl Gene ID: | ENSG00000112851 |
| VEGA IDs: | OTTHUMG00000097808 | UniProt ID: | Q96RT1 |
| UCSC ID: | uc003jui.1 | OMIM ID: | 606944 |
| Pubmed: | PMID10574462 PMID 10878805 | ||
| CCDS IDs: | CCDSCCDS3990.1 CCDS CCDS34172.1 | ||
Erbb2 interacting protein (ERBB2IP) also known as Erbin is a protein which in humans is encoded by the ERBB2IP gene.
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. [provided by RefSeq, Jul 2008].
Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
Products for ERBB2IP gene
| Catalog | Product Name | Application | Company |
| GFS:E04980 | erbb2 interacting protein; ELISA kit | ELISA | n/a |
| GFS:A04980 | erbb2 interacting protein; Anti | ANTIBODIES | n/a |
| GFS:P04980 | erbb2 interacting protein; Protien | Protien | n/a |
