Symbol: Name: ID: |
EPCAM epithelial cell adhesion molecule GFS:1385 |
Gene name: | EPCAM |
Chromosome: | 2p21 |
Previous Symbols: | M4S1, MIC18, TACSTD1 |
Previous Names: | antigen identified by monoclonal antibody AUA1, "tumor-associated calcium signal transducer 1" |
Aliases: | Ly74, TROP1, GA733-2, EGP34, EGP40, EGP-2, KSA, CD326, Ep-CAM, HEA125, KS1/4, MK-1, MH99, MOC31, 323/A3, 17-1A, TACST-1, CO-17A, ESA |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106653 | Rat Genome Database ID: | RGD:621365 |
HGNC ID: | HGNC:11529 | RefSeq IDs: | NM_002354 |
Entrez Gene ID: | 4072 | Ensembl Gene ID: | ENSG00000119888 |
VEGA IDs: | OTTHUMG00000128853 | UniProt ID: | P16422 |
UCSC ID: | uc002rvx.2 | OMIM ID: | 185535 |
Pubmed: | PMID8382772 PMID 11306819 | ||
CCDS IDs: | CCDSCCDS1833.1 |
Epithelial cell adhesion molecule (EpCAM) is a protein that in humans is encoded by the EPCAM gene. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. (provided by RefSeq)
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Products for EPCAM gene
Catalog | Product Name | Application | Company |
GFS:E01385 | epithelial cell adhesion molecule; ELISA kit | ELISA | n/a |
GFS:A01385 | epithelial cell adhesion molecule; Anti | ANTIBODIES | n/a |
GFS:P01385 | epithelial cell adhesion molecule; Protien | Protien | n/a |