Symbol: Name: ID: |
ERAP1 endoplasmic reticulum aminopeptidase 1 GFS:7059 |
Gene name: | ERAP1 |
Chromosome: | 5q15 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1 |
Name Aliases: | aminopeptidase regulator of TNFR1 shedding, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1933403 | Rat Genome Database ID: | RGD:708542 |
HGNC ID: | HGNC:18173 | RefSeq IDs: | NM_001040458 |
Entrez Gene ID: | 51752 | Ensembl Gene ID: | ENSG00000164307 |
VEGA IDs: | OTTHUMG00000128721 | UniProt ID: | Q9NZ08 |
UCSC ID: | uc003kml.2 | OMIM ID: | 606832 |
Pubmed: | PMID10220586 PMID 12189246 PMID 16286653 | ||
CCDS IDs: | CCDSCCDS4085.1 CCDS CCDS47250.1 |
Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as ARTS-1, is a protein which in humans is encoded by the ARTS-1 gene.
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Products for ERAP1 gene
Catalog | Product Name | Application | Company |
GFS:E07059 | endoplasmic reticulum aminopeptidase 1; ELISA kit | ELISA | n/a |
GFS:A07059 | endoplasmic reticulum aminopeptidase 1; Anti | ANTIBODIES | n/a |
GFS:P07059 | endoplasmic reticulum aminopeptidase 1; Protien | Protien | n/a |