| Symbol: Name: ID: |
ELAC2 elaC homolog 2 (E. coli) GFS:3581 |
| Gene name: | ELAC2 |
| Chromosome: | 17p11.2 |
| Previous Symbols: | |
| Previous Names: | elaC (E. coli) homolog 2 |
| Aliases: | FLJ10530, HPC2 |
| Name Aliases: | tRNase Z (long form) |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1890496 | Rat Genome Database ID: | RGD:628882 |
| HGNC ID: | HGNC:14198 | RefSeq IDs: | NM_001165962 |
| Entrez Gene ID: | 60528 | Ensembl Gene ID: | ENSG00000006744 |
| VEGA IDs: | OTTHUMG00000058764 | UniProt ID: | Q9BQ52 |
| UCSC ID: | uc002gnz.3 | OMIM ID: | 605367 |
| Pubmed: | PMID10986046 PMID 16636667 | ||
| CCDS IDs: | CCDSCCDS11164.1 | ||
Zinc phosphodiesterase ELAC protein 2 is an enzyme that in humans is encoded by the ELAC2 gene.
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Function: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Products for ELAC2 gene
| Catalog | Product Name | Application | Company |
| GFS:E03581 | elaC homolog 2 (E. coli); ELISA kit | ELISA | n/a |
| GFS:A03581 | elaC homolog 2 (E. coli); Anti | ANTIBODIES | n/a |
| GFS:P03581 | elaC homolog 2 (E. coli); Protien | Protien | n/a |
