Symbol: Name: ID: |
EDA2R ectodysplasin A2 receptor GFS:6671 |
Gene name: | EDA2R |
Chromosome: | Xq11.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | XEDAR, EDA-A2R, EDAA2R, TNFRSF27 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442860 | Rat Genome Database ID: | RGD:1564025 |
HGNC ID: | HGNC:17756 | RefSeq IDs: | NM_001199687 |
Entrez Gene ID: | 60401 | Ensembl Gene ID: | ENSG00000131080 |
VEGA IDs: | OTTHUMG00000021736 | UniProt ID: | Q9HAV5 |
UCSC ID: | uc004dwq.2 | OMIM ID: | 300276 |
Pubmed: | PMID11039935 | ||
CCDS IDs: | CCDSCCDS14386.1 |
Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the EDA2R gene.
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011].
Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Products for EDA2R gene
Catalog | Product Name | Application | Company |
GFS:E06671 | ectodysplasin A2 receptor; ELISA kit | ELISA | n/a |
GFS:A06671 | ectodysplasin A2 receptor; Anti | ANTIBODIES | n/a |
GFS:P06671 | ectodysplasin A2 receptor; Protien | Protien | n/a |