Symbol: Name: ID: |
DUOX2 dual oxidase 2 GFS:2915 |
Gene name: | DUOX2 |
Chromosome: | 15q15.3-q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | P138-TOX, P138(TOX), THOX2, LNOX2 |
Name Aliases: | dual oxidase-like domains 2, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3036280 | Rat Genome Database ID: | RGD:628761 |
HGNC ID: | HGNC:13273 | RefSeq IDs: | NM_014080 |
Entrez Gene ID: | 50506 | Ensembl Gene ID: | ENSG00000140279 |
VEGA IDs: | OTTHUMG00000131355 | UniProt ID: | Q9NRD8 |
UCSC ID: | uc010bea.2 | OMIM ID: | 606759 |
Pubmed: | PMID10601291 PMID 10806195 | ||
CCDS IDs: | CCDSCCDS10117.1 |
Dual oxidase 2, also known as DUOX2 or ThOX2 (for thyroid oxidase) is an enzyme which in humans is encoded by the DUOX2 gene.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Products for DUOX2 gene
Catalog | Product Name | Application | Company |
GFS:E02915 | dual oxidase 2; ELISA kit | ELISA | n/a |
GFS:A02915 | dual oxidase 2; Anti | ANTIBODIES | n/a |
GFS:P02915 | dual oxidase 2; Protien | Protien | n/a |