Symbol: Name: ID: |
DROSHA drosha, ribonuclease type III GFS:6804 |
Gene name: | DROSHA |
Chromosome: | 5q11.2 |
Previous Symbols: | RNASEN |
Previous Names: | ribonuclease type III, nuclear |
Aliases: | RNASE3L, Etohi2, HSA242976, RN3 |
Name Aliases: | drosha, ribonuclease type III, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1261425 | Rat Genome Database ID: | RGD:1307626 |
HGNC ID: | HGNC:17904 | RefSeq IDs: | NM_001100412 |
Entrez Gene ID: | 29102 | Ensembl Gene ID: | ENSG00000113360 |
VEGA IDs: | OTTHUMG00000161976 | UniProt ID: | Q9NRR4 |
UCSC ID: | uc003jhg.2 | OMIM ID: | 608828 |
Pubmed: | PMID10713462 PMID 10948199 | ||
CCDS IDs: | CCDSCCDS47194.1 CCDS CCDS47195.1 |
Ribonuclease 3 is an enzyme that in humans is encoded by the RNASEN gene.
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008].
Function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
Products for DROSHA gene
Catalog | Product Name | Application | Company |
GFS:E06804 | drosha, ribonuclease type III; ELISA kit | ELISA | n/a |
GFS:A06804 | drosha, ribonuclease type III; Anti | ANTIBODIES | n/a |
GFS:P06804 | drosha, ribonuclease type III; Protien | Protien | n/a |