Symbol: Name: ID: |
DAAM1 dishevelled associated activator of morphogenesis 1 GFS:7029 |
Gene name: | DAAM1 |
Chromosome: | 14q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0666 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914596 | Rat Genome Database ID: | RGD:1305119 |
HGNC ID: | HGNC:18142 | RefSeq IDs: | NM_014992 |
Entrez Gene ID: | 23002 | Ensembl Gene ID: | ENSG00000100592 |
VEGA IDs: | OTTHUMG00000140326 | UniProt ID: | Q9Y4D1 |
UCSC ID: | uc001xdz.1 | OMIM ID: | 606626 |
Pubmed: | PMID11779461 PMID 18162551 | ||
CCDS IDs: | CCDSCCDS9737.1 |
Disheveled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene.
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.
Products for DAAM1 gene
Catalog | Product Name | Application | Company |
GFS:E07029 | dishevelled associated activator of morphogenesis 1; ELISA kit | ELISA | n/a |
GFS:A07029 | dishevelled associated activator of morphogenesis 1; Anti | ANTIBODIES | n/a |
GFS:P07029 | dishevelled associated activator of morphogenesis 1; Protien | Protien | n/a |