Symbol: Name: ID: |
DICER1 dicer 1, ribonuclease type III GFS:6192 |
Gene name: | DICER1 |
Chromosome: | 14q32.2 |
Previous Symbols: | |
Previous Names: | Dicer1, Dcr-1 homolog (Drosophila) |
Aliases: | Dicer, KIAA0928, K12H4.8-LIKE, HERNA |
Name Aliases: | dicer 1, double-stranded RNA-specific endoribonuclease |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2177178 | Rat Genome Database ID: | RGD:1309381 |
HGNC ID: | HGNC:17098 | RefSeq IDs: | NM_001195573 |
Entrez Gene ID: | 23405 | Ensembl Gene ID: | ENSG00000100697 |
VEGA IDs: | UniProt ID: | Q9UPY3 | |
UCSC ID: | uc001ydw.2 | OMIM ID: | 606241 |
Pubmed: | PMID10051563 PMID 10786632 | ||
CCDS IDs: | CCDSCCDS9931.1 |
Dicer1, Dcr-1 homolog (Drosophila), also known as DICER1, is a protein which in humans is encoded by the DICER1 gene. It is present in many organisms as Dicer.
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Products for DICER1 gene
Catalog | Product Name | Application | Company |
GFS:E06192 | dicer 1, ribonuclease type III; ELISA kit | ELISA | n/a |
GFS:A06192 | dicer 1, ribonuclease type III; Anti | ANTIBODIES | n/a |
GFS:P06192 | dicer 1, ribonuclease type III; Protien | Protien | n/a |