Symbol: Name: ID: |
DCXR dicarbonyl/L-xylulose reductase GFS:7788 |
Gene name: | DCXR |
Chromosome: | 17q25.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIDCR, DCR, SDR20C1 |
Name Aliases: | short chain dehydrogenase/reductase family 20C, member 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915130 | Rat Genome Database ID: | RGD:620031 |
HGNC ID: | HGNC:18985 | RefSeq IDs: | NM_001195218 |
Entrez Gene ID: | 51181 | Ensembl Gene ID: | ENSG00000169738 |
VEGA IDs: | UniProt ID: | Q7Z4W1 | |
UCSC ID: | uc002kdg.2 | OMIM ID: | 608347 |
Pubmed: | PMID11882650 PMID 19027726 | ||
CCDS IDs: | CCDSCCDS11799.1 |
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010].
Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Products for DCXR gene
Catalog | Product Name | Application | Company |
GFS:E07788 | dicarbonyl/L-xylulose reductase; ELISA kit | ELISA | n/a |
GFS:A07788 | dicarbonyl/L-xylulose reductase; Anti | ANTIBODIES | n/a |
GFS:P07788 | dicarbonyl/L-xylulose reductase; Protien | Protien | n/a |