Symbol: Name: ID: |
DTX2 deltex homolog 2 (Drosophila) GFS:5105 |
Gene name: | DTX2 |
Chromosome: | 7q11.23 |
Previous Symbols: | |
Previous Names: | deltex (Drosophila) homolog 2 |
Aliases: | RNF58 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921448 | Rat Genome Database ID: | RGD:1561790 |
HGNC ID: | HGNC:15973 | RefSeq IDs: | NM_001102594 |
Entrez Gene ID: | 113878 | Ensembl Gene ID: | ENSG00000091073 |
VEGA IDs: | OTTHUMG00000022872 | UniProt ID: | Q86UW9 |
UCSC ID: | uc003ufh.3 | OMIM ID: | 613141 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS5587.1 CCDS CCDS43605.1 |
Protein deltex-2 is a protein that in humans is encoded by the DTX2 gene.
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009].
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Products for DTX2 gene
Catalog | Product Name | Application | Company |
GFS:E05105 | deltex homolog 2 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A05105 | deltex homolog 2 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P05105 | deltex homolog 2 (Drosophila); Protien | Protien | n/a |