Symbol: Name: ID: |
CRLF2 cytokine receptor-like factor 2 GFS:3645 |
Gene name: | CRLF2 |
Chromosome: | Xp22.3 and Yp11.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CRL2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889506 | Rat Genome Database ID: | RGD:621078 |
HGNC ID: | HGNC:14281 | RefSeq IDs: | NM_001012288 |
Entrez Gene ID: | 64109 | Ensembl Gene ID: | ENSG00000205755 |
VEGA IDs: | OTTHUMG00000067432 | UniProt ID: | Q9HC73 |
UCSC ID: | uc004cpk.1 | OMIM ID: | 300357 |
Pubmed: | PMID11237741 PMID 11474172 | ||
CCDS IDs: |
Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene.
Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM, Jul 2002]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
Products for CRLF2 gene
Catalog | Product Name | Application | Company |
GFS:E03645 | cytokine receptor-like factor 2; ELISA kit | ELISA | n/a |
GFS:A03645 | cytokine receptor-like factor 2; Anti | ANTIBODIES | n/a |
GFS:P03645 | cytokine receptor-like factor 2; Protien | Protien | n/a |