Symbol: Name: ID: |
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) GFS:7657 |
Gene name: | CFTR |
Chromosome: | 7q31-q32 |
Previous Symbols: | CF, ABCC7 |
Previous Names: | cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) |
Aliases: | MRP7, ABC35, TNR-CFTR, dJ760C5.1, CFTR/MRP |
Name Aliases: | ATP-binding cassette sub-family C, member 7 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88388 | Rat Genome Database ID: | RGD:2332 |
HGNC ID: | HGNC:1884 | RefSeq IDs: | NM_000492 |
Entrez Gene ID: | 1080 | Ensembl Gene ID: | ENSG00000001626 |
VEGA IDs: | OTTHUMG00000023076 | UniProt ID: | P13569 |
UCSC ID: | uc003vjd.2 | OMIM ID: | 602421 |
Pubmed: | PMID2772657 | ||
CCDS IDs: | CCDSCCDS5773.1 |
Cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that in humans is encoded by the CFTR gene.
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
Products for CFTR gene
Catalog | Product Name | Application | Company |
GFS:E07657 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); ELISA kit | ELISA | n/a |
GFS:A07657 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Anti | ANTIBODIES | n/a |
GFS:P07657 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Protien | Protien | n/a |