Symbol: Name: ID: |
CCNF cyclin F GFS:5043 |
Gene name: | CCNF |
Chromosome: | 16p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FBX1, FBXO1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102551 | Rat Genome Database ID: | RGD:67401 |
HGNC ID: | HGNC:1591 | RefSeq IDs: | NM_001761 |
Entrez Gene ID: | 899 | Ensembl Gene ID: | ENSG00000162063 |
VEGA IDs: | OTTHUMG00000128858 | UniProt ID: | P41002 |
UCSC ID: | uc002cqd.1 | OMIM ID: | 600227 |
Pubmed: | PMID7896286 | ||
CCDS IDs: | CCDSCCDS10467.1 |
G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008].
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Products for CCNF gene
Catalog | Product Name | Application | Company |
GFS:E05043 | cyclin F; ELISA kit | ELISA | n/a |
GFS:A05043 | cyclin F; Anti | ANTIBODIES | n/a |
GFS:P05043 | cyclin F; Protien | Protien | n/a |