Symbol: Name: ID: |
DMTF1 cyclin D binding myb-like transcription factor 1 GFS:3905 |
Gene name: | DMTF1 |
Chromosome: | 7q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DMP1, DMTF, hDMP1 |
Name Aliases: | cyclin D-binding Myb-like protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344415 | Rat Genome Database ID: | RGD:70966 |
HGNC ID: | HGNC:14603 | RefSeq IDs: | NM_001142326 |
Entrez Gene ID: | 9988 | Ensembl Gene ID: | ENSG00000135164 |
VEGA IDs: | OTTHUMG00000154135 | UniProt ID: | Q9Y222 |
UCSC ID: | uc003uih.2 | OMIM ID: | 608491 |
Pubmed: | PMID10095122 | ||
CCDS IDs: | CCDSCCDS5601.1 CCDS CCDS47633.1 |
Cyclin-D-binding Myb-like transcription factor 1 is a protein that in humans is encoded by the DMTF1 gene.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Products for DMTF1 gene
Catalog | Product Name | Application | Company |
GFS:E03905 | cyclin D binding myb-like transcription factor 1; ELISA kit | ELISA | n/a |
GFS:A03905 | cyclin D binding myb-like transcription factor 1; Anti | ANTIBODIES | n/a |
GFS:P03905 | cyclin D binding myb-like transcription factor 1; Protien | Protien | n/a |