Symbol: Name: ID: |
CCNC cyclin C GFS:4955 |
Gene name: | CCNC |
Chromosome: | 6q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CycC |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1858199 | Rat Genome Database ID: | RGD:70905 |
HGNC ID: | HGNC:1581 | RefSeq IDs: | NM_001013399 |
Entrez Gene ID: | 892 | Ensembl Gene ID: | ENSG00000112237 |
VEGA IDs: | OTTHUMG00000015268 | UniProt ID: | P24863 |
UCSC ID: | uc003pqe.2 | OMIM ID: | 123838 |
Pubmed: | PMID1833066 | ||
CCDS IDs: | CCDSCCDS34502.1 CCDS CCDS47461.1 |
Cyclin-C is a protein that in humans is encoded by the CCNC gene.
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Products for CCNC gene
Catalog | Product Name | Application | Company |
GFS:E04955 | cyclin C; ELISA kit | ELISA | n/a |
GFS:A04955 | cyclin C; Anti | ANTIBODIES | n/a |
GFS:P04955 | cyclin C; Protien | Protien | n/a |