Symbol: Name: ID: |
CCNA1 cyclin A1 GFS:4919 |
Gene name: | CCNA1 |
Chromosome: | 13q12.3-q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108042 | Rat Genome Database ID: | RGD:1310639 |
HGNC ID: | HGNC:1577 | RefSeq IDs: | NM_001111045 |
Entrez Gene ID: | 8900 | Ensembl Gene ID: | ENSG00000133101 |
VEGA IDs: | OTTHUMG00000016733 | UniProt ID: | P78396 |
UCSC ID: | uc001uvr.3 | OMIM ID: | 604036 |
Pubmed: | PMID9041194 | ||
CCDS IDs: | CCDSCCDS9357.1 CCDS CCDS45030.1 CCDS CCDS45031.1 |
Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Products for CCNA1 gene
Catalog | Product Name | Application | Company |
GFS:E04919 | cyclin A1; ELISA kit | ELISA | n/a |
GFS:A04919 | cyclin A1; Anti | ANTIBODIES | n/a |
GFS:P04919 | cyclin A1; Protien | Protien | n/a |