Symbol: Name: ID: |
CORIN corin, serine peptidase GFS:7814 |
Gene name: | CORIN |
Chromosome: | 4p13-p12 |
Previous Symbols: | |
Previous Names: | corin, serine protease |
Aliases: | PRSC, CRN, ATC2, Lrp4, TMPRSS10 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349451 | Rat Genome Database ID: | RGD:727887 |
HGNC ID: | HGNC:19012 | RefSeq IDs: | NM_006587 |
Entrez Gene ID: | 10699 | Ensembl Gene ID: | ENSG00000145244 |
VEGA IDs: | OTTHUMG00000099441 | UniProt ID: | Q9Y5Q5 |
UCSC ID: | uc003gxm.2 | OMIM ID: | 605236 |
Pubmed: | PMID10329693 | ||
CCDS IDs: | CCDSCCDS3477.1 |
Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
Products for CORIN gene
Catalog | Product Name | Application | Company |
GFS:E07814 | corin, serine peptidase; ELISA kit | ELISA | n/a |
GFS:A07814 | corin, serine peptidase; Anti | ANTIBODIES | n/a |
GFS:P07814 | corin, serine peptidase; Protien | Protien | n/a |