Symbol: Name: ID: |
CNTNAP2 contactin associated protein-like 2 GFS:3306 |
Gene name: | CNTNAP2 |
Chromosome: | 7q35 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Caspr2, KIAA0868, NRXN4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914047 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13830 | RefSeq IDs: | NM_014141 |
Entrez Gene ID: | 26047 | Ensembl Gene ID: | ENSG00000174469 |
VEGA IDs: | OTTHUMG00000152743 | UniProt ID: | Q9UHC6 |
UCSC ID: | uc003weu.1 | OMIM ID: | 604569 |
Pubmed: | PMID10624965 PMID 10048485 | ||
CCDS IDs: | CCDSCCDS5889.1 |
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene.
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for CNTNAP2 gene
Catalog | Product Name | Application | Company |
GFS:E03306 | contactin associated protein-like 2; ELISA kit | ELISA | n/a |
GFS:A03306 | contactin associated protein-like 2; Anti | ANTIBODIES | n/a |
GFS:P03306 | contactin associated protein-like 2; Protien | Protien | n/a |