Symbol: Name: ID: |
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa GFS:3334 |
Gene name: | CPSF6 |
Chromosome: | 12q15 |
Previous Symbols: | |
Previous Names: | cleavage and polyadenylation specific factor 6, 68kD subunit |
Aliases: | CFIM, HPBRII-4, HPBRII-7, CFIM68 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913948 | Rat Genome Database ID: | RGD:1304640 |
HGNC ID: | HGNC:13871 | RefSeq IDs: | NM_007007 |
Entrez Gene ID: | 11052 | Ensembl Gene ID: | ENSG00000111605 |
VEGA IDs: | UniProt ID: | Q16630 | |
UCSC ID: | uc001sut.3 | OMIM ID: | 604979 |
Pubmed: | PMID9659921 PMID 17267687 | ||
CCDS IDs: | CCDSCCDS8988.1 |
Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping
Products for CPSF6 gene
Catalog | Product Name | Application | Company |
GFS:E03334 | cleavage and polyadenylation specific factor 6, 68kDa; ELISA kit | ELISA | n/a |
GFS:A03334 | cleavage and polyadenylation specific factor 6, 68kDa; Anti | ANTIBODIES | n/a |
GFS:P03334 | cleavage and polyadenylation specific factor 6, 68kDa; Protien | Protien | n/a |