Clarin-1 is a protein that in humans is encoded by the CLRN1 gene.

This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Function: May have a role in the excitory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.