Symbol: Name: ID: |
CCKBR cholecystokinin B receptor GFS:4872 |
Gene name: | CCKBR |
Chromosome: | 11p15.4 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99479 | Rat Genome Database ID: | RGD:2290 |
HGNC ID: | HGNC:1571 | RefSeq IDs: | NM_176875 |
Entrez Gene ID: | 887 | Ensembl Gene ID: | ENSG00000110148 |
VEGA IDs: | OTTHUMG00000133380 | UniProt ID: | P32239 |
UCSC ID: | uc001mcp.2 | OMIM ID: | 118445 |
Pubmed: | PMID1280419 | ||
CCDS IDs: | CCDSCCDS7761.1 |
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene.
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous systemwhere they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
Products for CCKBR gene
Catalog | Product Name | Application | Company |
GFS:E04872 | cholecystokinin B receptor; ELISA kit | ELISA | n/a |
GFS:A04872 | cholecystokinin B receptor; Anti | ANTIBODIES | n/a |
GFS:P04872 | cholecystokinin B receptor; Protien | Protien | n/a |