Symbol: Name: ID: |
CBY1 chibby homolog 1 (Drosophila) GFS:2766 |
Gene name: | CBY1 |
Chromosome: | 22q12 |
Previous Symbols: | C22orf2, PGEA1 |
Previous Names: | chromosome 22 open reading frame 2, "PKD2 interactor, golgi and endoplasmic reticulum associated 1" |
Aliases: | PIGEA14, PIGEA-14, Chibby, Cby |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920989 | Rat Genome Database ID: | RGD:708481 |
HGNC ID: | HGNC:1307 | RefSeq IDs: | NM_001002880 |
Entrez Gene ID: | 25776 | Ensembl Gene ID: | ENSG00000100211 |
VEGA IDs: | OTTHUMG00000150990 | UniProt ID: | Q9Y3M2 |
UCSC ID: | uc003awb.2 | OMIM ID: | 607757 |
Pubmed: | PMID10591208 PMID 15194699 | ||
CCDS IDs: | CCDSCCDS13974.1 |
Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Products for CBY1 gene
Catalog | Product Name | Application | Company |
GFS:E02766 | chibby homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A02766 | chibby homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P02766 | chibby homolog 1 (Drosophila); Protien | Protien | n/a |