Symbol: Name: ID: |
CXCL12 chemokine (C-X-C motif) ligand 12 GFS:595 |
Gene name: | CXCL12 |
Chromosome: | 10q11.1 |
Previous Symbols: | SDF1A, SDF1B, SDF1 |
Previous Names: | stromal cell-derived factor 1 |
Aliases: | SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103556 | Rat Genome Database ID: | RGD:3651 |
HGNC ID: | HGNC:10672 | RefSeq IDs: | NM_000609 |
Entrez Gene ID: | 6387 | Ensembl Gene ID: | ENSG00000107562 |
VEGA IDs: | OTTHUMG00000018054 | UniProt ID: | P48061 |
UCSC ID: | uc001jbh.2 | OMIM ID: | 600835 |
Pubmed: | PMID7490086 | ||
CCDS IDs: | CCDSCCDS7207.1 CCDS CCDS31186.1 CCDS CCDS44373.1 |
CXCL12 encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase
Products for CXCL12 gene
Catalog | Product Name | Application | Company |
GFS:E00595 | chemokine (C-X-C motif) ligand 12; ELISA kit | ELISA | n/a |
GFS:A00595 | chemokine (C-X-C motif) ligand 12; Anti | ANTIBODIES | n/a |
GFS:P00595 | chemokine (C-X-C motif) ligand 12; Protien | Protien | n/a |