Symbol: Name: ID: |
CBLN1 cerebellin 1 precursor GFS:4649 |
Gene name: | CBLN1 |
Chromosome: | 16q12.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88281 | Rat Genome Database ID: | RGD:1562813 |
HGNC ID: | HGNC:1543 | RefSeq IDs: | NM_004352 |
Entrez Gene ID: | 869 | Ensembl Gene ID: | ENSG00000102924 |
VEGA IDs: | OTTHUMG00000133148 | UniProt ID: | P23435 |
UCSC ID: | uc002efq.2 | OMIM ID: | 600432 |
Pubmed: | PMID7877445 PMID 1704129 | ||
CCDS IDs: | CCDSCCDS10736.1 |
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Function: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3 (By similarity) .
Function: Cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).
Products for CBLN1 gene
Catalog | Product Name | Application | Company |
GFS:E04649 | cerebellin 1 precursor; ELISA kit | ELISA | n/a |
GFS:A04649 | cerebellin 1 precursor; Anti | ANTIBODIES | n/a |
GFS:P04649 | cerebellin 1 precursor; Protien | Protien | n/a |