Symbol: Name: ID: |
CENPH centromere protein H GFS:6349 |
Gene name: | CENPH |
Chromosome: | 5p15.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NNF1, PMF1 |
Name Aliases: | NNF1, MIND kinetochore complex component, homolog (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349448 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17268 | RefSeq IDs: | NM_022909 |
Entrez Gene ID: | 64946 | Ensembl Gene ID: | ENSG00000153044 |
VEGA IDs: | OTTHUMG00000097816 | UniProt ID: | Q9H3R5 |
UCSC ID: | uc003jvp.2 | OMIM ID: | 605607 |
Pubmed: | PMID11092768 PMID 15502821 | ||
CCDS IDs: | CCDSCCDS3998.1 |
Centromere protein H is a protein that in humans is encoded by the CENPH gene.
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Products for CENPH gene
Catalog | Product Name | Application | Company |
GFS:E06349 | centromere protein H; ELISA kit | ELISA | n/a |
GFS:A06349 | centromere protein H; Anti | ANTIBODIES | n/a |
GFS:P06349 | centromere protein H; Protien | Protien | n/a |