Symbol: Name: ID: |
CENPB centromere protein B, 80kDa GFS:7368 |
Gene name: | CENPB |
Chromosome: | 20p13 |
Previous Symbols: | |
Previous Names: | centromere protein B (80kD) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88376 | Rat Genome Database ID: | RGD:1304794 |
HGNC ID: | HGNC:1852 | RefSeq IDs: | NM_001810 |
Entrez Gene ID: | 1059 | Ensembl Gene ID: | ENSG00000125817 |
VEGA IDs: | OTTHUMG00000031761 | UniProt ID: | P07199 |
UCSC ID: | uc002wjk.2 | OMIM ID: | 117140 |
Pubmed: | PMID8406460 PMID 11884609 | ||
CCDS IDs: | CCDSCCDS13064.1 |
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
Products for CENPB gene
Catalog | Product Name | Application | Company |
GFS:E07368 | centromere protein B, 80kDa; ELISA kit | ELISA | n/a |
GFS:A07368 | centromere protein B, 80kDa; Anti | ANTIBODIES | n/a |
GFS:P07368 | centromere protein B, 80kDa; Protien | Protien | n/a |