Symbol: Name: ID: |
CENPA centromere protein A GFS:7358 |
Gene name: | CENPA |
Chromosome: | 2p24-p21 |
Previous Symbols: | |
Previous Names: | centromere protein A (17kD), "centromere protein A, 17kDa" |
Aliases: | CENP-A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88375 | Rat Genome Database ID: | RGD:1563607 |
HGNC ID: | HGNC:1851 | RefSeq IDs: | NM_001042426 |
Entrez Gene ID: | 1058 | Ensembl Gene ID: | ENSG00000115163 |
VEGA IDs: | OTTHUMG00000097073 | UniProt ID: | P49450 |
UCSC ID: | uc002rhr.2 | OMIM ID: | 117139 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS1729.1 CCDS CCDS42662.1 |
Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene.
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
Products for CENPA gene
Catalog | Product Name | Application | Company |
GFS:E07358 | centromere protein A; ELISA kit | ELISA | n/a |
GFS:A07358 | centromere protein A; Anti | ANTIBODIES | n/a |
GFS:P07358 | centromere protein A; Protien | Protien | n/a |