Symbol: Name: ID: |
CLCF1 cardiotrophin-like cytokine factor 1 GFS:6475 |
Gene name: | CLCF1 |
Chromosome: | 11q13.3 |
Previous Symbols: | |
Previous Names: | CRLF1 associated cytokine-like factor 1 |
Aliases: | NNT1, BSF3, CLC, NR6, CISS2 |
Name Aliases: | B-cell stimulating factor 3, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930088 | Rat Genome Database ID: | RGD:1303171 |
HGNC ID: | HGNC:17412 | RefSeq IDs: | NM_001166212 |
Entrez Gene ID: | 23529 | Ensembl Gene ID: | ENSG00000175505 |
VEGA IDs: | UniProt ID: | Q9UBD9 | |
UCSC ID: | uc001okq.2 | OMIM ID: | 607672 |
Pubmed: | PMID10500198 PMID 10448081 PMID 16782820 | ||
CCDS IDs: | CCDSCCDS31617.1 |
Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
Function: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
Products for CLCF1 gene
Catalog | Product Name | Application | Company |
GFS:E06475 | cardiotrophin-like cytokine factor 1; ELISA kit | ELISA | n/a |
GFS:A06475 | cardiotrophin-like cytokine factor 1; Anti | ANTIBODIES | n/a |
GFS:P06475 | cardiotrophin-like cytokine factor 1; Protien | Protien | n/a |