Symbol: Name: ID: |
CBR1 carbonyl reductase 1 GFS:4688 |
Gene name: | CBR1 |
Chromosome: | 21q22.1 |
Previous Symbols: | CBR |
Previous Names: | |
Aliases: | SDR21C1 |
Name Aliases: | short chain dehydrogenase/reductase family 21C, member 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88284 | Rat Genome Database ID: | RGD:2286 |
HGNC ID: | HGNC:1548 | RefSeq IDs: | NM_001757 |
Entrez Gene ID: | 873 | Ensembl Gene ID: | ENSG00000159228 |
VEGA IDs: | OTTHUMG00000086618 | UniProt ID: | P16152 |
UCSC ID: | uc002yvb.1 | OMIM ID: | 114830 |
Pubmed: | PMID8432528 PMID 19027726 | ||
CCDS IDs: | CCDSCCDS13641.1 |
Carbonyl reductase 1, also known as CBR1, is an enzyme which in humans is encoded by the CBR1 gene.
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Products for CBR1 gene
Catalog | Product Name | Application | Company |
GFS:E04688 | carbonyl reductase 1; ELISA kit | ELISA | n/a |
GFS:A04688 | carbonyl reductase 1; Anti | ANTIBODIES | n/a |
GFS:P04688 | carbonyl reductase 1; Protien | Protien | n/a |