Symbol: Name: ID: |
CLSTN1 calsyntenin 1 GFS:6497 |
Gene name: | CLSTN1 |
Chromosome: | 1p36.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CSTN1, KIAA0911, CDHR12 |
Name Aliases: | cadherin-related family member 12 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929895 | Rat Genome Database ID: | RGD:1306458 |
HGNC ID: | HGNC:17447 | RefSeq IDs: | NM_001009566 |
Entrez Gene ID: | 22883 | Ensembl Gene ID: | ENSG00000171603 |
VEGA IDs: | OTTHUMG00000001451 | UniProt ID: | O94985 |
UCSC ID: | uc001aqh.2 | OMIM ID: | 611321 |
Pubmed: | PMID10048485 | ||
CCDS IDs: | CCDSCCDS105.1 CCDS CCDS30580.1 |
Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.
Function: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Products for CLSTN1 gene
Catalog | Product Name | Application | Company |
GFS:E06497 | calsyntenin 1; ELISA kit | ELISA | n/a |
GFS:A06497 | calsyntenin 1; Anti | ANTIBODIES | n/a |
GFS:P06497 | calsyntenin 1; Protien | Protien | n/a |