Symbol: Name: ID: |
CANX calnexin GFS:4013 |
Gene name: | CANX |
Chromosome: | 5q35 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CNX, IP90, P90 |
Name Aliases: | major histocompatibility complex class I antigen-binding protein p88 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88261 | Rat Genome Database ID: | RGD:2266 |
HGNC ID: | HGNC:1473 | RefSeq IDs: | NM_001024649 |
Entrez Gene ID: | 821 | Ensembl Gene ID: | ENSG00000127022 |
VEGA IDs: | OTTHUMG00000130910 | UniProt ID: | P27824 |
UCSC ID: | uc003mkl.2 | OMIM ID: | 114217 |
Pubmed: | PMID1326756 PMID 8136357 | ||
CCDS IDs: | CCDSCCDS4447.1 |
Calnexin (CNX) is a 90kDa integral protein of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Products for CANX gene
Catalog | Product Name | Application | Company |
GFS:E04013 | calnexin; ELISA kit | ELISA | n/a |
GFS:A04013 | calnexin; Anti | ANTIBODIES | n/a |
GFS:P04013 | calnexin; Protien | Protien | n/a |