Symbol: Name: ID: |
CALD1 caldesmon 1 GFS:3751 |
Gene name: | CALD1 |
Chromosome: | 7q33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CDM, H-CAD, L-CAD |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88250 | Rat Genome Database ID: | RGD:2256 |
HGNC ID: | HGNC:1441 | RefSeq IDs: | NM_004342 |
Entrez Gene ID: | 800 | Ensembl Gene ID: | ENSG00000122786 |
VEGA IDs: | OTTHUMG00000155407 | UniProt ID: | Q05682 |
UCSC ID: | uc003vrz.2 | OMIM ID: | 114213 |
Pubmed: | PMID1885618 | ||
CCDS IDs: | CCDSCCDS5834.1 CCDS CCDS5835.1 CCDS CCDS5836.1 CCDS CCDS47716.1 CCDS CCDS47717.1 |
Caldesmon is a protein that in humans is encoded by the CALD1 gene.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
Products for CALD1 gene
Catalog | Product Name | Application | Company |
GFS:E03751 | caldesmon 1; ELISA kit | ELISA | n/a |
GFS:A03751 | caldesmon 1; Anti | ANTIBODIES | n/a |
GFS:P03751 | caldesmon 1; Protien | Protien | n/a |