Symbol: Name: ID: |
CASR calcium-sensing receptor GFS:4397 |
Gene name: | CASR |
Chromosome: | 3q21.1 |
Previous Symbols: | HHC, HHC1 |
Previous Names: | hypocalciuric hypercalcemia 1 |
Aliases: | FHH, NSHPT, GPRC2A |
Name Aliases: | severe neonatal hyperparathyroidism |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351351 | Rat Genome Database ID: | RGD:2277 |
HGNC ID: | HGNC:1514 | RefSeq IDs: | NM_000388 |
Entrez Gene ID: | 846 | Ensembl Gene ID: | ENSG00000036828 |
VEGA IDs: | OTTHUMG00000159491 | UniProt ID: | P41180 |
UCSC ID: | uc003eev.3 | OMIM ID: | 601199 |
Pubmed: | PMID7677761 | ||
CCDS IDs: | CCDSCCDS3010.1 |
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008].
Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Products for CASR gene
Catalog | Product Name | Application | Company |
GFS:E04397 | calcium-sensing receptor; ELISA kit | ELISA | n/a |
GFS:A04397 | calcium-sensing receptor; Anti | ANTIBODIES | n/a |
GFS:P04397 | calcium-sensing receptor; Protien | Protien | n/a |