Symbol: Name: ID: |
CIB1 calcium and integrin binding 1 (calmyrin) GFS:6007 |
Gene name: | CIB1 |
Chromosome: | 15q25.3-q26 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SIP2-28, CALMYRIN, CIB, KIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344418 | Rat Genome Database ID: | RGD:620133 |
HGNC ID: | HGNC:16920 | RefSeq IDs: | NM_006384 |
Entrez Gene ID: | 10519 | Ensembl Gene ID: | ENSG00000185043 |
VEGA IDs: | OTTHUMG00000149808 | UniProt ID: | Q99828 |
UCSC ID: | uc002bpb.3 | OMIM ID: | 602293 |
Pubmed: | PMID9030514 PMID 10826701 | ||
CCDS IDs: | CCDSCCDS10360.1 |
Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
Products for CIB1 gene
Catalog | Product Name | Application | Company |
GFS:E06007 | calcium and integrin binding 1 (calmyrin); ELISA kit | ELISA | n/a |
GFS:A06007 | calcium and integrin binding 1 (calmyrin); Anti | ANTIBODIES | n/a |
GFS:P06007 | calcium and integrin binding 1 (calmyrin); Protien | Protien | n/a |